How cutting calories changes molecular signs of aging
Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11251729
Researchers are comparing molecular changes caused by calorie restriction in rhesus monkeys to learn how those changes might help people age healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11251729 on ClinicalTrials.gov |
What this research studies
This project looks at tissues from rhesus monkeys that have been on long-term calorie restriction to find molecular patterns linked to slower aging. Scientists profile genes, proteins, lipids, and RNA-based regulators across multiple tissues and map how those molecules interact within and between organs. The team uses advanced molecular and bioinformatics methods to build interaction networks that show which pathways calorie restriction affects. Results are compared to known age-related pathways so findings can be connected to human aging and disease risk.
Who could benefit from this research
Good fit: This grant does not enroll people; its findings are most relevant to older adults (for example age 65+) and adults interested in interventions to slow aging.
Not a fit: Children and people seeking immediate clinical treatments for an existing disease are unlikely to receive direct benefit from this primate-based basic research.
Why it matters
Potential benefit: If successful, the work could point to molecular targets or biomarkers to delay age-related diseases and improve healthy lifespan in older adults.
How similar studies have performed: Long-term calorie restriction studies in rhesus monkeys from the same program have already shown improved health and survival, and this project builds on those molecular findings.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSON, ROZALYN M. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: ANDERSON, ROZALYN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.