How CTRP6 affects fat tissue and inflammation
Immunometabolic Regulation of Adipose Tissue by CTRP6
['FUNDING_R15'] · OKLAHOMA STATE UNIVERSITY STILLWATER · NIH-10796306
This study is looking at a protein called CTRP6 to see how it affects immune cells in fat tissue, with the hope of finding new ways to reduce inflammation and help people with obesity-related health problems feel better.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA STATE UNIVERSITY STILLWATER (nih funded) |
| Locations | 1 site (STILLWATER, UNITED STATES) |
| Trial ID | NIH-10796306 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CTRP6, a protein that influences how immune cells called macrophages behave in fat tissue. By altering the polarization of these macrophages, the study aims to reduce inflammation and improve insulin sensitivity, which are critical factors in obesity-related conditions. The researchers will use advanced techniques, including CRISPR/Cas9 gene editing, to create macrophages that lack CTRP6 and assess their effects on inflammation and insulin resistance. This approach could lead to new therapies for managing obesity-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity and related metabolic disorders, particularly those experiencing inflammation and insulin resistance.
Not a fit: Patients who do not have obesity or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reduce inflammation and improve insulin sensitivity in patients with obesity-related conditions.
How similar studies have performed: Previous research has shown promising results in targeting macrophage polarization for treating obesity-related inflammation, indicating that this approach has potential for success.
Where this research is happening
STILLWATER, UNITED STATES
- OKLAHOMA STATE UNIVERSITY STILLWATER — STILLWATER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEI, XIA — OKLAHOMA STATE UNIVERSITY STILLWATER
- Study coordinator: LEI, XIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.