How CTRP6 affects fat tissue and inflammation
Official title: Immunometabolic Regulation of Adipose Tissue by CTRP6
Funded at Oklahoma State University Stillwater · NIH-10796306 · Data updated 2026-11-12
This study is looking at a protein called CTRP6 to see how it affects immune cells in fat tissue, with the hope of finding new ways to reduce inflammation and help people with obesity-related health problems feel better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $442,844 |
| NIH project number | 1R15DK136102-01A1 |
| Project ID | NIH-10796306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity and related metabolic disorders, particularly those experiencing inflammation and insulin resistance.
✕Less likely to help
Patients who do not have obesity or related metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of CTRP6, a protein that influences how immune cells called macrophages behave in fat tissue. By altering the polarization of these macrophages, the study aims to reduce inflammation and improve insulin sensitivity, which are critical factors in obesity-related conditions. The researchers will use advanced techniques, including CRISPR/Cas9 gene editing, to create macrophages that lack CTRP6 and assess their effects on inflammation and insulin resistance. This approach could lead to new therapies for managing obesity-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reduce inflammation and improve insulin sensitivity in patients with obesity-related conditions.
How similar studies have gone: Previous research has shown promising results in targeting macrophage polarization for treating obesity-related inflammation, indicating that this approach has potential for success.
Where this research is happening
-
Oklahoma State University Stillwater
Stillwater, United States Active
Researchers
- Principal investigator: Lei, Xia — Oklahoma State University Stillwater
- Study coordinator: Lei, Xia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.