How CREBBP gene changes drive common B-cell lymphomas
Role of CREBBP missense mutations in lymphomagenesis
This research looks at how specific changes in the CREBBP gene in B cells may cause and point to new treatments for follicular lymphoma and diffuse large B-cell lymphoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11247933 on NIH RePORTER |
What this research studies
If you have follicular lymphoma or diffuse large B-cell lymphoma, researchers are studying CREBBP mutations that often appear early in tumor development. They will examine tumor samples and laboratory models to see how these missense mutations change protein acetylation, alter chromatin accessibility (using ATAC-seq), and affect antigen presentation. The team will combine genomic and biochemical experiments to find molecular weaknesses caused by these mutations. Findings could help direct future therapies or trials for patients whose tumors carry CREBBP alterations.
Who could benefit from this research
Good fit: Ideal candidates are people with follicular lymphoma or diffuse large B-cell lymphoma, particularly those whose tumor testing shows CREBBP mutations.
Not a fit: Patients without B-cell lymphoma or whose tumors do not carry CREBBP mutations are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to new targeted treatments or clinical trials for patients with CREBBP-mutant lymphomas.
How similar studies have performed: Previous studies have repeatedly identified CREBBP mutations in these lymphomas, but turning that knowledge into effective targeted therapies remains largely experimental.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Pasqualucci, Laura — Columbia University Health Sciences
- Study coordinator: Pasqualucci, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.