How COVID-19 vaccines affect immune responses in people living with HIV
Immune response to COVID-19 vaccine in HIV infected men and women
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10897067
This study is looking at how well COVID-19 vaccines work for people living with HIV compared to those without HIV, focusing on their immune responses and how the vaccine affects the HIV in their bodies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10897067 on ClinicalTrials.gov |
What this research studies
This research investigates the immune response to COVID-19 vaccines in individuals living with HIV, comparing their responses to those of HIV-uninfected individuals. The study will involve a detailed analysis of antibody production and immune cell responses in a cohort of vaccinated men and women with HIV. Researchers will also examine how the vaccine impacts the persistent HIV reservoir in these patients. By utilizing advanced machine learning techniques, the study aims to predict vaccine responses based on various immune parameters.
Who could benefit from this research
Good fit: Ideal candidates for this research are men and women living with HIV who are vaccinated against COVID-19.
Not a fit: Patients who are not living with HIV or who have not received a COVID-19 vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies for individuals living with HIV, enhancing their protection against COVID-19.
How similar studies have performed: Other research has shown promising results in understanding vaccine responses in immunocompromised populations, making this study a valuable continuation of that work.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RINALDO, CHARLES R — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: RINALDO, CHARLES R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus