How Coronins control cell movement and protein recycling
Regulation of membrane trafficking by Coronins
This study is looking at how a protein called Coro7 helps cells move and stay healthy by managing waste and misfolded proteins, which is important for everyone who wants to understand how our cells work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11076279 on NIH RePORTER |
What this research studies
This research investigates the role of Coronins, a family of proteins, in regulating actin networks that are crucial for cell movement, shape, and the transport of materials within cells. By using advanced techniques such as biochemical assays and live imaging, the study aims to understand how a specific Coronin, Coro7, interacts with other proteins to influence these processes. The findings could shed light on how cells manage misfolded proteins and other cellular debris through a process called autophagy, which is essential for maintaining cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions associated with protein misfolding, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein misfolding or actin regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how cells handle misfolded proteins, potentially benefiting patients with diseases related to protein misfolding.
How similar studies have performed: While the role of canonical Coronins has been studied, the specific focus on the tandem Coronins and their unique functions is relatively novel and has not been extensively tested.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Jansen, Silvia — Washington University
- Study coordinator: Jansen, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.