How coronaviruses that come from animals get into human cells
Functional Viromics of Betacoronavirus Entry
This project looks at how animal coronaviruses can enter human cells to help prevent future pandemics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11251212 on NIH RePORTER |
What this research studies
Researchers will analyze genetic data from tens of thousands of animal coronaviruses and test viral proteins in the laboratory to see how they interact with cells. They will use cell-based assays, receptor-binding tests, and functional screens to identify which viral changes allow entry into human cells. The team may also use animal models and samples from wildlife surveillance to confirm which viruses pose a spillover risk. Results will be used to flag viruses of concern and inform public-health monitoring.
Who could benefit from this research
Good fit: This grant does not enroll patients; it focuses on laboratory and animal experiments rather than clinical participation.
Not a fit: People currently sick with COVID-19 are unlikely to receive direct or immediate benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could identify animal coronaviruses that can infect people and guide better surveillance, vaccines, or treatments to prevent future outbreaks.
How similar studies have performed: Previous viromics and receptor-binding studies have identified zoonotic coronaviruses before, but this project applies broader functional screens at larger scale.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Letko, Michael — Washington State University
- Study coordinator: Letko, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.