How copper helps the body adapt to low oxygen levels
Novel roles of copper in adaptive responses to hypoxia
This study is looking at how copper helps our bodies respond when there's not enough oxygen, which is important for people with conditions that affect oxygen levels, and it uses special technology to see how changes in certain genes might impact how copper and iron work together to make red blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11113863 on NIH RePORTER |
What this research studies
This research investigates the role of copper in the body's response to low oxygen levels, known as hypoxia. It uses advanced CRISPR technology to identify how mutations in specific genes affect copper transport and its relationship with iron in the blood. By studying these mechanisms in both cultured cells and animal models, the research aims to uncover how copper can influence the production of red blood cells under hypoxic conditions. This could lead to a better understanding of diseases related to oxygen transport and metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting oxygen transport, such as anemia or certain genetic disorders.
Not a fit: Patients with conditions unrelated to copper metabolism or oxygen transport may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like anemia and other diseases related to oxygen transport.
How similar studies have performed: Other research has shown promising results in understanding the role of copper in metabolic processes, making this approach both relevant and potentially impactful.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Petris, Michael J. — University of Missouri-Columbia
- Study coordinator: Petris, Michael J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.