How controlled diets affect gut health and brain function
Project 2 - Influence of controlled diets on gut microbiome, metabolome and cognitive function
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10693930
This study is looking at how different diets can change the bacteria in our gut and how those changes might affect our brain health, especially for people concerned about Alzheimer's disease, so participants will follow specific eating plans to help us learn more about this connection.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10693930 on ClinicalTrials.gov |
What this research studies
This research investigates how different dietary interventions can influence the gut microbiome, which is the community of microorganisms in our intestines, and how these changes may impact cognitive function, particularly in relation to Alzheimer's disease. By analyzing blood and fecal samples, the study aims to identify metabolic changes associated with diet and their potential effects on brain health. Patients may participate in controlled dietary programs to help researchers understand the relationship between diet, gut health, and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing cognitive decline or are at risk for Alzheimer's disease.
Not a fit: Patients who are not experiencing cognitive decline or who have other neurological conditions unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help slow cognitive decline and improve brain health in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in understanding the link between diet, gut microbiome, and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KADDURAH-DAOUK, RIMA F — DUKE UNIVERSITY
- Study coordinator: KADDURAH-DAOUK, RIMA F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome