How congenital hyperinsulinism affects brain development in children
Official title: Impact of Congenital Hyperinsulinism on Trajectories of Neurocognitive Function Across School Age
Funded at Children's Hosp of Philadelphia · NIH-10916464 · Data updated 2026-11-12
This study is looking at how congenital hyperinsulinism (HI) affects the thinking and learning abilities of children aged 0-11, comparing their growth to that of healthy kids, and it will track changes over time to see how low blood sugar episodes might influence their brain development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $181,166 |
| NIH project number | 5K23DK136967-02 |
| Project ID | NIH-10916464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with congenital hyperinsulinism, particularly those experiencing varying durations of hypoglycemia.
✕Less likely to help
Patients who do not have congenital hyperinsulinism or those outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates the impact of congenital hyperinsulinism (HI) on neurocognitive development in children aged 0-11 years. It aims to identify different patterns of cognitive growth in children with HI compared to healthy peers, focusing on how the timing and duration of hypoglycemia exposure influence cognitive outcomes. The study will involve administering a series of neurocognitive tests at the start and again after one and two years to assess changes over time. By understanding these trajectories, the research seeks to uncover critical factors that may affect brain development in children with this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management strategies for cognitive deficits in children with congenital hyperinsulinism.
How similar studies have gone: Previous research has shown that understanding neurodevelopmental trajectories in similar pediatric conditions can lead to significant advancements in treatment and care.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Rosenfeld, Elizabeth — Children's Hosp of Philadelphia
- Study coordinator: Rosenfeld, Elizabeth
Related research
Other NIH-funded projects on the same topics.
-
Emotional and biobehavioral links in parent-infant closeness
A program to understand how parent and baby feel and react to each other in early life, with the goal of guiding better child social and emotional development.
-
Leukodystrophy Clinical Careers and Mentorship Network
A program to train, mentor, and support clinicians and researchers to advance care for people with leukodystrophies.
-
Role of ATP1A3 mutations in sudden death related to epilepsy
Aims to understand how ATP1A3 gene changes may lead to sudden death in kids with epilepsy and is exploring new ways to prevent it.
-
Kids First Data Resource Center: cloud-enabled data sharing for childhood cancer research
A data resource project that makes pediatric cancer data and analyses more accessible to researchers, with the goal of advancing understanding and care for children with cancer.
-
PROMISE: A Network for Real-World Evidence in Rare Pediatric Cancers
A network will collect and harmonize pediatric cancer patient records from multiple centers to create high-quality real-world data that can support quicker, regulatory-ready insights when randomized trials aren’t feasible.
-
Data Hub Core for Down syndrome research
A data hub project is building a big, interoperable platform to securely share and analyze information from people with Down syndrome and related conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.