How congenital hyperinsulinism affects brain development in children
Impact of Congenital Hyperinsulinism on Trajectories of Neurocognitive Function Across School Age
This study is looking at how congenital hyperinsulinism (HI) affects the thinking and learning abilities of children aged 0-11, comparing their growth to that of healthy kids, and it will track changes over time to see how low blood sugar episodes might influence their brain development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10916464 on NIH RePORTER |
What this research studies
This research investigates the impact of congenital hyperinsulinism (HI) on neurocognitive development in children aged 0-11 years. It aims to identify different patterns of cognitive growth in children with HI compared to healthy peers, focusing on how the timing and duration of hypoglycemia exposure influence cognitive outcomes. The study will involve administering a series of neurocognitive tests at the start and again after one and two years to assess changes over time. By understanding these trajectories, the research seeks to uncover critical factors that may affect brain development in children with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with congenital hyperinsulinism, particularly those experiencing varying durations of hypoglycemia.
Not a fit: Patients who do not have congenital hyperinsulinism or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management strategies for cognitive deficits in children with congenital hyperinsulinism.
How similar studies have performed: Previous research has shown that understanding neurodevelopmental trajectories in similar pediatric conditions can lead to significant advancements in treatment and care.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Rosenfeld, Elizabeth — Children's Hosp of Philadelphia
- Study coordinator: Rosenfeld, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.