How compounds from gut bacteria can help improve mobility in older adults
Official title: Indoles from commensal microbiota promote mobility during aging
Funded at Emory University · NIH-11170332 · Data updated 2026-11-12
This study is looking at how certain good bacteria in our gut produce helpful compounds that might improve movement and health as we get older, focusing on how these compounds can help our muscles and reduce inflammation for better mobility in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 26, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $387,006 |
| NIH project number | 1R56AG086417-01 |
| Project ID | NIH-11170332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing mobility issues or frailty.
✕Less likely to help
Patients who are younger or do not have mobility issues may not benefit from this research.
What this research studies
This research investigates the role of indoles, which are compounds produced by beneficial gut bacteria, in promoting mobility and health as people age. The study examines how these compounds interact with the body's systems to enhance muscle protein stability and reduce inflammation, potentially leading to better mobility in older adults. By analyzing samples from various organisms, including humans, the research aims to understand the connection between gut microbiota and physical health in aging. The findings could provide insights into how maintaining a healthy gut microbiome can support mobility and overall well-being in the elderly.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving mobility and quality of life in older adults.
How similar studies have gone: Previous studies have indicated that gut microbiota and their metabolites can significantly influence health outcomes, suggesting a promising avenue for this research.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kalman, Daniel — Emory University
- Study coordinator: Kalman, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.