How complement affects immune cells in kidney transplants
Complement regulates macrophage and platelet function in kidney transplants
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10908389
This study is looking at how certain proteins in your immune system affect kidney transplants, especially how they interact with immune cells, to see if blocking these proteins can help people who are having trouble with their transplants.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10908389 on ClinicalTrials.gov |
What this research studies
This research investigates the role of complement proteins in the immune response during kidney transplants, particularly focusing on how they influence macrophages and platelets. The study aims to understand whether therapeutic inhibitors of complement can improve outcomes in patients experiencing antibody-mediated rejection. By examining the effects of complement components like C1q and C5a, the research seeks to clarify their roles in inflammation and immune cell behavior. Patients may benefit from insights that could lead to improved treatments for transplant rejection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing kidney transplantation or those experiencing complications related to transplant rejection.
Not a fit: Patients who are not undergoing kidney transplantation or those with stable graft function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of kidney transplant rejection, improving patient outcomes and graft survival.
How similar studies have performed: Previous research has shown promising results with complement inhibitors in similar contexts, suggesting potential for success in this area.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALDWIN, WILLIAM M — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: BALDWIN, WILLIAM M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.