How communication between the endoplasmic reticulum and mitochondria affects calcium signaling and liver health
ER-mitochondrial communication in calcium signaling, energy metabolism and liver disease
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-11017027
This study is looking at how the endoplasmic reticulum and mitochondria in your liver cells communicate with each other, especially how calcium signals affect energy use and liver health, to find new ways to treat liver diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11017027 on ClinicalTrials.gov |
What this research studies
This research investigates the communication between the endoplasmic reticulum (ER) and mitochondria, focusing on how calcium signaling influences energy metabolism and liver disease. By studying how calcium is released from the ER and its effects on mitochondrial function, the research aims to uncover mechanisms that could lead to better understanding and treatment of liver conditions. The team uses innovative synthetic membrane linkers to observe and manipulate these interactions in live cells, providing insights into cellular metabolism and signaling pathways. This work could help identify new therapeutic targets for liver diseases linked to metabolic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver diseases, particularly those related to metabolic dysfunction such as fatty liver disease.
Not a fit: Patients with liver diseases not related to calcium signaling or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases by improving our understanding of cellular energy metabolism and calcium signaling.
How similar studies have performed: Previous research has shown promising results in understanding the role of ER-mitochondrial communication in various diseases, indicating that this approach has potential for significant findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAJNOCZKY, GYORGY — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: HAJNOCZKY, GYORGY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.