How common low-count monoclonal B-cell lymphocytosis (MBL) is, what may cause it, and what it means for patients
Prevalence, etiology, and clinical implications of low count monoclonal B-cell lymphocytosis (MBL)
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-11045496
This project looks at how common low-count MBL is, what might cause it, and how it can affect adults over 40.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11045496 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers will look for small clonal B-cell populations in blood samples and classify them by cell markers and clone size. They will combine blood testing, genetic analyses, and review of medical records to learn possible causes and risk factors. The team will follow people over time to see who remains stable and who might progress toward blood cancer. Findings are intended to clarify differences between low-count and high-count MBL and to inform follow-up care.
Who could benefit from this research
Good fit: Ideal candidates are adults, especially those over age 40, who have blood tests showing clonal B-cells or who are willing to provide blood samples for B-cell testing and follow-up.
Not a fit: People without clonal B-cells in their blood or those with conditions unrelated to B-cell disorders are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help doctors decide who with low-count MBL needs closer monitoring and who can be safely observed without intervention.
How similar studies have performed: Previous observational studies have shown that some MBL cases can precede chronic lymphocytic leukemia, but the behavior and risks for low-count MBL are still not well defined.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SLAGER, SUSAN L — MAYO CLINIC ROCHESTER
- Study coordinator: SLAGER, SUSAN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.