How collagen gene changes harm lung development in osteogenesis imperfecta
Lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta
This work looks at whether changes in collagen genes cause lung problems in people with osteogenesis imperfecta.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11146620 on NIH RePORTER |
What this research studies
Researchers use mouse models that carry the same collagen mutations seen in osteogenesis imperfecta to study how lungs form and work. They examine lung tissue structure, which lung cell types are lost or altered, and measure breathing mechanics over time. The team uses modern gene-expression mapping techniques and comparisons across different genetic models to pinpoint molecular and cellular causes. Findings aim to clarify whether lung problems come from the lung itself rather than only from chest or spine deformities.
Who could benefit from this research
Good fit: People with osteogenesis imperfecta or related collagen disorders — especially infants and children who have early breathing or lung development issues — would be most relevant to these findings.
Not a fit: People whose breathing problems are unrelated to collagen mutations or who have lung issues caused only by non-collagen conditions are less likely to benefit from this work.
Why it matters
Potential benefit: If successful, this work could point to new ways to detect, monitor, or treat lung problems in people with osteogenesis imperfecta.
How similar studies have performed: Previous animal studies have shown altered lung cells and breathing mechanics in OI models, but applying those findings to human care remains a new and developing area.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Morello, Roy — Univ of Arkansas for Med Scis
- Study coordinator: Morello, Roy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.