How collagen changes during breast cancer spread
Regulation of collagen linearization during cancer progression and metastasis
This study is looking at how a protein called collagen helps aggressive breast cancer grow and spread, and it’s specifically checking out how a factor from the tumor cells, called WISP1, changes collagen to make it easier for cancer to invade other areas; the goal is to find new ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11042172 on NIH RePORTER |
What this research studies
This research investigates the role of collagen, a key protein in the tumor environment, in the progression and spread of aggressive breast cancer. It focuses on understanding how cancer cells remodel collagen to facilitate their invasion and metastasis. The study will explore the mechanisms by which a specific factor secreted by tumor cells, known as WISP1, influences collagen linearization and promotes cancer spread. By identifying these processes, the research aims to uncover potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with aggressive breast cancer who are experiencing or at risk of metastasis.
Not a fit: Patients with non-aggressive forms of breast cancer or those without metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit cancer spread and improve outcomes for patients with aggressive breast cancer.
How similar studies have performed: Other research has shown promising results in understanding the role of the tumor microenvironment in cancer progression, suggesting that this approach could yield significant insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Labelle, Myriam — St. Jude Children's Research Hospital
- Study coordinator: Labelle, Myriam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.