How collagen affects the growth and metabolism of pancreatic cancer.
Official title: Collagen fibers and fragments regulate pancreatic cancer metabolism and growth.
Funded at University of California, San Diego · NIH-11045786 · Data updated 2026-11-12
This study is looking at how different parts of collagen, a protein in our bodies, affect the growth of pancreatic cancer cells, and it aims to find new ways to help improve treatment for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $639,881 |
| NIH project number | 5R01CA285997-02 |
| Project ID | NIH-11045786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma.
✕Less likely to help
Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the role of collagen fibers and their fragments in pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer. It aims to understand how these collagen components interact with cancer cells and influence their growth and metabolism. By using preclinical models and clinical specimens, the study will explore the contrasting effects of intact collagen fibers versus cleaved collagen fragments on cancer progression. The findings could provide insights into potential therapeutic strategies for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatment approaches that enhance survival rates for patients with pancreatic cancer.
How similar studies have gone: Other research has shown promising results in understanding the role of the tumor microenvironment in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Karin, Michael — University of California, San Diego
- Study coordinator: Karin, Michael
Related research
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-
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-
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-
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-
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.