How collagen affects the growth and metabolism of pancreatic cancer.
Collagen fibers and fragments regulate pancreatic cancer metabolism and growth.
This study is looking at how different parts of collagen, a protein in our bodies, affect the growth of pancreatic cancer cells, and it aims to find new ways to help improve treatment for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11045786 on NIH RePORTER |
What this research studies
This research investigates the role of collagen fibers and their fragments in pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer. It aims to understand how these collagen components interact with cancer cells and influence their growth and metabolism. By using preclinical models and clinical specimens, the study will explore the contrasting effects of intact collagen fibers versus cleaved collagen fragments on cancer progression. The findings could provide insights into potential therapeutic strategies for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma.
Not a fit: Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment approaches that enhance survival rates for patients with pancreatic cancer.
How similar studies have performed: Other research has shown promising results in understanding the role of the tumor microenvironment in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Karin, Michael — University of California, San Diego
- Study coordinator: Karin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.