How cocaine-related cues affect relapse in adolescents
Official title: Impact of cocaine-associated cues and contexts on adolescent relapse
Funded at Michigan State University · NIH-11055041 · Data updated 2026-11-12
This study looks at how reminders and situations linked to cocaine use can lead to cravings and relapse in young people, using adolescent rats to learn more about the brain changes that happen when they stop using cocaine.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $78,500 |
| NIH project number | 1R03DA060344-01A1 |
| Project ID | NIH-11055041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adolescents aged 12 to 20 who have a history of cocaine use or are at risk for substance use disorders.
✕Less likely to help
Patients who are not adolescents or who do not have a history of cocaine use may not receive benefit from this research.
What this research studies
This research investigates how cues and contexts associated with cocaine use influence relapse behaviors in adolescents. By studying adolescent rats, the researchers aim to understand the brain and behavioral changes that occur during periods of abstinence from cocaine. The study will explore how these cues trigger cravings and relapse, focusing on the differences between adolescents and adults. The findings could provide insights into the mechanisms behind substance use disorders in young people.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for adolescents at risk of substance use disorders.
How similar studies have gone: Previous research has shown that understanding the role of environmental cues in relapse can lead to effective interventions, suggesting that this approach has potential for success.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Arguello, Amy a — Michigan State University
- Study coordinator: Arguello, Amy a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.