How cocaine affects dopamine release in the brain
Cocaine effects on spatial patterns of striatal dopamine release
This study is looking at how cocaine addiction affects the brain's reward system, specifically how it changes the release of a chemical called dopamine, to help find better treatments for people dealing with cocaine use disorder.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11101280 on NIH RePORTER |
What this research studies
This research investigates the impact of cocaine use disorder on dopamine release in a specific brain region known as the nucleus accumbens core. It aims to understand how cocaine alters the brain's ability to process both rewarding and aversive stimuli, which is crucial for developing effective treatments for individuals struggling with cocaine addiction. The study will utilize advanced techniques to measure dopamine release in response to various stimuli in animal models, providing insights into the underlying mechanisms of addiction. By examining these processes, the research seeks to identify potential therapeutic targets for improving treatment outcomes in patients with cocaine use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use disorder or those affected by cocaine addiction.
Not a fit: Patients who do not have a history of cocaine use or those with other substance use disorders unrelated to cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals suffering from cocaine use disorder.
How similar studies have performed: Previous research has shown promising results in understanding dopamine signaling in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Elam, Hannah — Vanderbilt University
- Study coordinator: Elam, Hannah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.