How CMV viremia affects brain infections in people with advanced HIV
Official title: Impact of longitudinal CMV viremia on opportunistic neuroinfections in advanced HIV disease
Funded at University of Minnesota · NIH-11080579 · Data updated 2026-11-12
This study is looking at how cytomegalovirus (CMV) affects the brains of people with advanced HIV, aiming to find better ways to prevent and treat serious brain infections, especially in areas of Africa where resources are limited.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $239,490 |
| NIH project number | 1K23NS137968-01A1 |
| Project ID | NIH-11080579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with advanced HIV disease who are experiencing or are at risk for CMV viremia and related neuroinfections.
✕Less likely to help
Patients who are not affected by HIV or those with early-stage HIV without opportunistic infections may not benefit from this research.
What this research studies
This research investigates the relationship between cytomegalovirus (CMV) viremia and opportunistic neuroinfections in individuals with advanced HIV disease. The study aims to improve understanding of how CMV impacts the central nervous system and contributes to mortality in this population. By conducting clinical trials and utilizing translational immunology research, the project seeks to develop effective treatment and prevention strategies for these infections, particularly in resource-limited settings in Africa. The research will involve collaboration with an interdisciplinary team to enhance knowledge and skills in clinical trial design and execution.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment and prevention strategies for opportunistic brain infections in patients with advanced HIV, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promising results in understanding the impact of CMV on HIV-related conditions, but this specific approach focusing on neuroinfections is relatively novel.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Skipper, Caleb P — University of Minnesota
- Study coordinator: Skipper, Caleb P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.