How claudin proteins affect mucus function in the gut
Claudin expression regulates mucus function
This study is looking at how certain proteins in the intestines affect mucus, which is important for people with Inflammatory Bowel Diseases like Crohn's and Ulcerative Colitis, to help find better treatment options.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hawaii Pacific University NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-10515281 on NIH RePORTER |
What this research studies
This research investigates the role of claudin proteins in regulating mucus function within the intestines, particularly in the context of Inflammatory Bowel Diseases (IBDs) like Crohn's Disease and Ulcerative Colitis. The study aims to understand how inflammation alters claudin expression and disrupts the mucus barrier, potentially leading to disease progression. Using a knockout mouse model, researchers will explore the relationship between claudin proteins and mucus consistency, as well as evaluate the effectiveness of dietary therapies. This approach may provide insights into new treatment strategies for patients suffering from IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Crohn's Disease or Ulcerative Colitis, particularly those experiencing severe symptoms or inadequate response to current treatments.
Not a fit: Patients with IBD who are not experiencing significant symptoms or those who have already found effective management strategies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing Inflammatory Bowel Diseases, enhancing patient quality of life.
How similar studies have performed: While the specific approach of linking claudin expression to mucus function in IBD is novel, similar studies have shown promise in understanding the role of gut barriers in inflammatory conditions.
Where this research is happening
Honolulu, United States
- Hawaii Pacific University — Honolulu, United States (Active)
Researchers
- Principal investigator: Capaldo, Christopher Todd — Hawaii Pacific University
- Study coordinator: Capaldo, Christopher Todd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.