How circadian rhythms affect muscle function and aging
Official title: Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11000147 · Data updated 2026-11-12
This study is looking at how our body's natural daily rhythms affect muscle health and aging, and it’s testing a compound called Nobiletin to see if it can help improve muscle function and overall fitness, which could be really helpful for anyone wanting to stay active and healthy as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $507,325 |
| NIH project number | 1R01AG089967-01 |
| Project ID | NIH-11000147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are interested in maintaining their physical fitness and health as they age.
✕Less likely to help
Patients with acute muscle injuries or those who are not experiencing age-related decline may not benefit from this research.
What this research studies
This research investigates the role of circadian rhythms in maintaining muscle health and promoting healthy aging. It focuses on the ROR (Retinoid acid receptor-related Orphan Receptor) proteins, which are crucial for regulating these rhythms. By studying the effects of a specific compound called Nobiletin on muscle function and mitochondrial health, the research aims to uncover new strategies to enhance physical fitness and reduce age-related decline. Patients may benefit from insights into how their daily rhythms influence their health and potential interventions to improve their well-being.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle function and overall health in aging individuals.
How similar studies have gone: Previous studies have shown promising results in using circadian rhythm modulation to improve health outcomes, suggesting that this approach may be effective.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Chen, Zheng — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Chen, Zheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.