How circadian rhythm disruptions affect diabetes and heart disease
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11085092
This study is looking at how changes in our body clocks, like those faced by people who work night shifts, can lead to problems with insulin and increase the risk of diabetes and heart disease, and it aims to find ways to help prevent these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11085092 on ClinicalTrials.gov |
What this research studies
This research investigates how disruptions in circadian rhythms, such as those experienced by shift workers, contribute to insulin resistance and type 2 diabetes, as well as increase the risk of atherovascular disease. The study aims to understand the molecular mechanisms behind these effects and to explore potential interventions that could mitigate the health risks associated with circadian disruption. By examining genetic and environmental factors in animal models, the researchers hope to identify effective strategies to protect against these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who experience circadian rhythm disruptions, such as shift workers or those with irregular sleep patterns.
Not a fit: Patients who do not have issues related to circadian rhythm disruptions or those without diabetes or atherovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that help prevent or treat diabetes and heart disease linked to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown that circadian rhythm disruptions can lead to metabolic issues, but this specific approach to intervention is novel and has not been extensively tested.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YECHOOR, VIJAY K — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: YECHOOR, VIJAY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus