How circadian clock proteins affect the immune system
The role of circadian clock proteins in innate and adaptive immunity
This study is looking at how our body's internal clock and light exposure can help boost our immune system, especially when fighting infections like sepsis and pneumonia, and it could lead to new ways to use light therapy to keep us healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10708936 on NIH RePORTER |
What this research studies
This research investigates the role of circadian clock proteins in regulating immune responses in the body. By studying how these proteins interact with light and influence immune function, the research aims to understand how timing and environmental cues can enhance the body's ability to fight infections. The approach includes using animal models to observe the effects of light exposure on immune responses during sepsis and pneumonia. The findings could lead to new strategies for improving immune function through light therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with compromised immune systems or those at risk for infections.
Not a fit: Patients with stable immune function or those not experiencing infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance immune responses in patients, particularly during infections.
How similar studies have performed: Previous research has shown promising results in using light exposure to enhance immune function, suggesting that this approach may be effective.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Rosengart, Matthew Randall — Washington University
- Study coordinator: Rosengart, Matthew Randall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.