How chylomicrons affect blood vessel cells and contribute to heart disease
Official title: Chylomicrons and endothelial biology
Funded at New York University School of Medicine · NIH-11001203 · Data updated 2026-11-12
This study is looking at how tiny fat particles called chylomicrons affect the health of your blood vessels and may play a role in the early stages of heart disease, helping us understand how to keep your arteries healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $745,095 |
| NIH project number | 5R01HL160891-03 |
| Project ID | NIH-11001203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for atherosclerosis, such as those with high cholesterol or a family history of heart disease.
✕Less likely to help
Patients who do not have risk factors for atherosclerosis or existing cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the role of chylomicrons, a type of fat particle, in the development of atherosclerosis, a condition that can lead to heart disease. The study focuses on how these particles interact with endothelial cells, which line blood vessels, and how they contribute to lipid accumulation in the arteries. By examining the mechanisms of chylomicron uptake and processing by endothelial cells, the researchers aim to uncover new insights into the early stages of atherosclerosis. The research includes both laboratory experiments and in vivo studies to assess the impact of chylomicrons on vascular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown that understanding lipid interactions with endothelial cells can provide valuable insights into cardiovascular disease, suggesting that this approach may yield significant findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Goldberg, Ira J — New York University School of Medicine
- Study coordinator: Goldberg, Ira J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.