How chronic viral infections affect the immune system in organ transplant patients
Immune control of chronic viral infection in solid organ transplantation
This study is looking at how a virus called Cytomegalovirus (CMV) affects the immune system of people who have received organ transplants, especially how it might make their immune cells age faster and impact their ability to fight infections and respond to vaccines, with the goal of finding better ways to support their immune health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project ID | NIH-10928049 on NIH RePORTER |
What this research studies
This research investigates how latent Cytomegalovirus (CMV) affects the immune response in patients who have undergone solid organ transplantation. It focuses on understanding the accelerated aging of immune cells, particularly T and B cells, in these patients and how this impacts their ability to respond to infections and vaccinations. By studying a network of transplant centers, the research aims to uncover the long-term effects of CMV on immune function post-transplant. The findings could lead to improved strategies for managing immune health in transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have received solid organ transplants and are latently infected with Cytomegalovirus.
Not a fit: Patients who have not undergone organ transplantation or are not infected with Cytomegalovirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the immune responses of organ transplant patients, leading to better health outcomes and reduced complications from infections.
How similar studies have performed: Previous research has shown that understanding the immune response in transplant patients can lead to significant advancements in patient care, indicating that this approach has potential for success.
Where this research is happening
Palo Alto, United States
- Veterans Admin Palo Alto Health Care Sys — Palo Alto, United States (Active)
Researchers
- Principal investigator: Maltzman, Jonathan S — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Maltzman, Jonathan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.