How chronic stress affects brain signaling differently in males and females
Sex differences in CRH signaling in the ovBNST underlie effects of chronic stressors
This study is looking at how long-term stress affects the brain, especially in a specific area that might work differently in men and women, to help us understand why some people develop anxiety and mood issues when they're stressed, and it could lead to better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10808104 on NIH RePORTER |
What this research studies
This research investigates how chronic stress impacts the brain's signaling pathways, particularly focusing on a specific area known as the oval nucleus of the bed nucleus of the stria terminalis (ovBNST). It aims to understand the differences in stress responses between males and females by examining the role of certain hormones and receptors in this brain region. By studying rodent models, the research will explore how chronic stress alters neuronal activity and behavior, potentially leading to anxiety and mood disorders. The findings could provide insights into the biological mechanisms behind stress-related conditions and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing stress-related mood disorders, particularly those with anxiety symptoms.
Not a fit: Patients who do not experience stress-related mood disorders or those with conditions unrelated to chronic stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for stress-related mood disorders, particularly those that manifest differently in men and women.
How similar studies have performed: Other research has shown success in understanding the effects of chronic stress on brain function, but this specific focus on sex differences in the ovBNST is relatively novel.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Roepke, Troy Adam — Rutgers, the State Univ of N.j.
- Study coordinator: Roepke, Troy Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.