How chronic stress affects brain function and behavior
Chronic stress-induced REDD1 expression in prefrontal cortex and cognitive inflexibility
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11069589
This study looks at how long-term stress affects our ability to think and adapt, especially in people with major depressive disorder, and aims to find out how stress changes the brain so we can develop better treatments and coping methods for those dealing with stress-related issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11069589 on ClinicalTrials.gov |
What this research studies
This research investigates how chronic stress impacts cognitive flexibility, which is the ability to adapt behavior in response to changing situations. It focuses on understanding the biological mechanisms in the prefrontal cortex that may lead to cognitive deficits seen in conditions like major depressive disorder. By studying both animal models and human brain function, the research aims to uncover how stress alters brain structures and functions, particularly in males. The findings could help identify new targets for treatment and improve coping strategies for those affected by stress-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive difficulties related to chronic stress or major depressive disorder.
Not a fit: Patients with cognitive issues not related to stress or depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive deficits associated with chronic stress and depression.
How similar studies have performed: Previous research has shown that understanding the biological effects of stress on cognition can lead to significant advancements in treatment strategies.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANTSCH, JOHN R. — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MANTSCH, JOHN R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.