How chronic seizures affect mental health in Alzheimer's disease models
Impact of Chronic Seizures on Neuropsychiatric Comorbidities in AD-Associated Models
This study looks at how chronic seizures might affect mental health and behavior in people with Alzheimer's, especially those with certain genetic traits, to help us understand the long-term effects of seizures on their overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10862858 on NIH RePORTER |
What this research studies
This research investigates the relationship between chronic seizures and neuropsychiatric conditions in models of Alzheimer's disease. It focuses on understanding how these seizures, particularly in patients with specific genetic mutations, may worsen mental health outcomes and behavioral issues. The study employs preclinical models to explore the effects of seizures on neuroplasticity and associated protein expression over time. By examining these interactions, the research aims to provide insights into the long-term impacts of seizures on Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with early-onset Alzheimer's disease who also experience chronic seizures.
Not a fit: Patients without Alzheimer's disease or those who do not experience seizures are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for Alzheimer's patients experiencing seizures, potentially enhancing their overall quality of life.
How similar studies have performed: While the specific focus on chronic seizures in Alzheimer's models is relatively novel, there is existing evidence linking seizures with neuropsychiatric comorbidities in other contexts.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Barker-Haliski, Melissa Leigh — University of Washington
- Study coordinator: Barker-Haliski, Melissa Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.