How chronic alcohol use affects sleep regulation in the brain.
Neuronal mechanisms mediating the effects of chronic alcohol consumption on sleep homeostasis.
This study is looking at how drinking too much alcohol affects sleep problems, like insomnia, in people with alcohol use disorder, to help understand why these sleep issues happen and how they might lead to a relapse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10687817 on NIH RePORTER |
What this research studies
This research investigates the relationship between chronic alcohol consumption and sleep disturbances, particularly insomnia, in individuals with alcohol use disorder (AUD). It aims to understand the underlying mechanisms in the brain that disrupt sleep homeostasis due to alcohol intake. Using advanced techniques like calcium imaging and pharmacogenetics, the study will explore how alcohol affects specific brain pathways involved in sleep regulation. The findings could provide insights into why sleep issues are common in those with AUD and how they may contribute to relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who experience insomnia or other sleep-related issues.
Not a fit: Patients who do not have alcohol use disorder or those without sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sleep disturbances in patients with alcohol use disorder, potentially reducing relapse rates.
How similar studies have performed: Previous research has shown that understanding the neurobiological mechanisms of sleep disturbances in AUD can lead to effective interventions, suggesting that this approach has potential for success.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Thakkar, Mahesh M — University of Missouri-Columbia
- Study coordinator: Thakkar, Mahesh M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.