How chromosomes are arranged during development and adulthood
Chromosome organization in development and adulthood
['FUNDING_OTHER'] · SONOMA STATE UNIVERSITY · NIH-11116850
This project explores how human cells keep maternal and paternal chromosome sets apart during development and adulthood to prevent genetic errors that can lead to disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SONOMA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (ROHNERT PARK, UNITED STATES) |
| Trial ID | NIH-11116850 on ClinicalTrials.gov |
What this research studies
Researchers will use high-resolution imaging to watch chromosomes move in dividing human cells and in a mouse model that carries an extra chromosome. They map where each chromosome sits relative to the centrosome and a narrow 'diminished zone' that separates the two haploid sets. The team will compare normal primary human cells to kidney cancer cells to see when and how the anti-pairing arrangement breaks down. The work aims to reveal cellular mechanisms that stop harmful chromosome pairing during growth and tissue maintenance.
Who could benefit from this research
Good fit: Adults (21+) and people with renal (kidney) carcinoma or those who can provide tissue samples would be the most relevant candidates for related future studies.
Not a fit: People seeking immediate clinical treatments or children under 21 are unlikely to receive direct benefit from this basic laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could clarify how genome instability arises and point to new ways to prevent or detect cancers and other genetic disorders.
How similar studies have performed: High-resolution imaging and chromosome-tracking methods have previously shown organized chromosome positioning, but applying these findings to prevent mitotic pairing and genome instability is a newer research direction.
Where this research is happening
ROHNERT PARK, UNITED STATES
- SONOMA STATE UNIVERSITY — ROHNERT PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUA, LISA L — SONOMA STATE UNIVERSITY
- Study coordinator: HUA, LISA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.