How chromosomes and sex affect bone mass and strength
Contribution of chromosome versus gonadal sex to bone mass and strength
This study is looking at how male and female bodies differ in bone strength and density, using mice to explore how chromosomes and hormones affect bones as they grow, with the hope of finding ways to help prevent or treat bone loss for everyone.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10666647 on NIH RePORTER |
What this research studies
This research investigates the differences in bone mass and strength between males and females, focusing on the roles of chromosomes and sex hormones. By studying mice, the researchers aim to understand how these factors contribute to bone density and structure throughout different life stages. The study employs advanced imaging techniques to analyze bone characteristics and seeks to identify mechanisms that could lead to targeted treatments for bone loss. The ultimate goal is to develop strategies that can help prevent or reverse bone deterioration in both sexes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be at risk for bone density loss or osteoporosis.
Not a fit: Patients who are not at risk for bone density issues or who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone health and prevent osteoporosis in both men and women.
How similar studies have performed: Other research has shown promising results in understanding bone health through similar approaches, indicating potential for significant advancements in this area.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Plotkin, Lilian Irene — Indiana University Indianapolis
- Study coordinator: Plotkin, Lilian Irene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.