How chromosome separation works during egg cell development
Regulation of chromosome segregation during oocyte meiosis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-10930805
This study looks at how egg cells divide and make sure they have the right number of chromosomes, using tiny worms called C. elegans to learn more about mistakes that can happen during this process, which might help us understand and improve issues like miscarriages and birth defects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10930805 on ClinicalTrials.gov |
What this research studies
This research investigates the process of meiosis, which is the specialized cell division that produces egg cells with the correct number of chromosomes. By studying the model organism C. elegans, the research aims to understand how errors in chromosome segregation occur in female egg cells, which can lead to conditions like aneuploidy, a major cause of miscarriages and birth defects. The project focuses on the unique mechanisms of chromosome organization and separation in oocytes, particularly in the absence of centrosomes, which are typically involved in cell division. The findings could provide insights into improving reproductive health and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing recurrent miscarriages or those with a history of chromosomal abnormalities in their pregnancies.
Not a fit: Patients who are not planning to conceive or who do not have a history of reproductive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of miscarriages and birth defects caused by chromosomal abnormalities.
How similar studies have performed: Other research has shown promising results in understanding meiosis and its implications for reproductive health, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIGNALL, SARAH MARIE — NORTHWESTERN UNIVERSITY
- Study coordinator: WIGNALL, SARAH MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.