How chromosome organization affects cell behavior and cancer risk
Chromosome breakage, pairing and replication: impacts on cell fate and function
This study looks at how the arrangement of chromosomes in fruit fly cells affects their ability to break, fix themselves, or replicate, which could help us understand similar issues in humans that might lead to cancer or genetic problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10833128 on NIH RePORTER |
What this research studies
This research investigates how the structure and organization of chromosomes within the cell nucleus influence their behavior, particularly focusing on chromosome breakage, repair, and replication in fruit flies. By generating specific types of chromosomes that typically break, the study aims to understand how cells decide to repair these breaks or allow them to lead to cell death. The findings could provide insights into how similar processes might affect human health, especially in relation to cancer development and genetic mutations passed on through gametes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or genetic disorders related to chromosome abnormalities.
Not a fit: Patients with established cancer diagnoses unrelated to chromosome breakage or repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cancer mechanisms and improve strategies for preventing genetic mutations in future generations.
How similar studies have performed: Previous research has shown that understanding chromosome behavior can lead to significant advancements in cancer treatment and prevention, indicating that this approach has potential for success.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Golic, Kent G — University of Utah
- Study coordinator: Golic, Kent G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.