How chromosome copy number affects antibiotic tolerance in Pseudomonas aeruginosa
Official title: Examining the influence of chromosome copy number on Pseudomonas aeruginosa persisters to fluoroquinolones
Funded at Princeton University · NIH-11139248 · Data updated 2026-11-12
This study looks at how the number of chromosome copies in the bacteria Pseudomonas aeruginosa affects its ability to survive fluoroquinolone antibiotics, which could help find better ways to treat patients with chronic infections caused by this germ.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | April 15, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $205,000 |
| NIH project number | 1R21AI185486-01A1 |
| Project ID | NIH-11139248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are patients suffering from chronic infections caused by Pseudomonas aeruginosa.
✕Less likely to help
Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not receive any benefit from this research.
What this research studies
This research investigates how the number of chromosome copies in Pseudomonas aeruginosa influences its ability to survive treatment with fluoroquinolone antibiotics. The study focuses on understanding the mechanisms behind antibiotic tolerance, particularly in persister cells that can evade treatment and contribute to chronic infections. By examining the genetic factors that affect survival rates, the research aims to identify potential targets for improving antibiotic efficacy. Patients with chronic infections caused by this bacterium may benefit from the findings.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown that understanding genetic factors in antibiotic tolerance can lead to significant advancements in treatment strategies, indicating a promising avenue for this study.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Brynildsen, Mark P — Princeton University
- Study coordinator: Brynildsen, Mark P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.