How chromosome copy number affects antibiotic tolerance in Pseudomonas aeruginosa
Examining the influence of chromosome copy number on Pseudomonas aeruginosa persisters to fluoroquinolones
This study looks at how the number of chromosome copies in the bacteria Pseudomonas aeruginosa affects its ability to survive fluoroquinolone antibiotics, which could help find better ways to treat patients with chronic infections caused by this germ.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11139248 on NIH RePORTER |
What this research studies
This research investigates how the number of chromosome copies in Pseudomonas aeruginosa influences its ability to survive treatment with fluoroquinolone antibiotics. The study focuses on understanding the mechanisms behind antibiotic tolerance, particularly in persister cells that can evade treatment and contribute to chronic infections. By examining the genetic factors that affect survival rates, the research aims to identify potential targets for improving antibiotic efficacy. Patients with chronic infections caused by this bacterium may benefit from the findings.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are patients suffering from chronic infections caused by Pseudomonas aeruginosa.
Not a fit: Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Previous research has shown that understanding genetic factors in antibiotic tolerance can lead to significant advancements in treatment strategies, indicating a promising avenue for this study.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Brynildsen, Mark P — Princeton University
- Study coordinator: Brynildsen, Mark P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.