How chromatin organization affects gene regulation and memory in cells
Spatial Regulation of Epigenetic Memory
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10923236
This study looks at how the arrangement of DNA in our cells affects how genes are turned on and off, especially in diseases like cancer, and it aims to find new ways to help keep those genes in check during cell growth and division.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10923236 on ClinicalTrials.gov |
What this research studies
This research investigates how the spatial organization of chromatin, the material that makes up chromosomes, influences gene regulation and epigenetic memory in cells. It focuses on the role of specific proteins that modify chromatin structure and how these modifications can impact cellular processes, particularly in the context of diseases like cancer. By exploring the dynamic interactions between chromatin regions, the research aims to uncover new mechanisms that could help maintain gene repression during cell division and development, potentially leading to innovative therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or other diseases where epigenetic regulation plays a significant role.
Not a fit: Patients with conditions unrelated to epigenetic changes or chromatin organization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment by improving our understanding of gene regulation and epigenetic memory.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and its implications for gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURPHY, SEDONA — YALE UNIVERSITY
- Study coordinator: MURPHY, SEDONA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers