How chromatin organization affects gene regulation and memory in cells
Official title: Spatial Regulation of Epigenetic Memory
Funded at Yale University · NIH-10923236 · Data updated 2026-11-12
This study looks at how the arrangement of DNA in our cells affects how genes are turned on and off, especially in diseases like cancer, and it aims to find new ways to help keep those genes in check during cell growth and division.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 19, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 1DP5OD037361-01 |
| Project ID | NIH-10923236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or other diseases where epigenetic regulation plays a significant role.
✕Less likely to help
Patients with conditions unrelated to epigenetic changes or chromatin organization may not benefit from this research.
What this research studies
This research investigates how the spatial organization of chromatin, the material that makes up chromosomes, influences gene regulation and epigenetic memory in cells. It focuses on the role of specific proteins that modify chromatin structure and how these modifications can impact cellular processes, particularly in the context of diseases like cancer. By exploring the dynamic interactions between chromatin regions, the research aims to uncover new mechanisms that could help maintain gene repression during cell division and development, potentially leading to innovative therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment by improving our understanding of gene regulation and epigenetic memory.
How similar studies have gone: Previous research has shown promising results in understanding chromatin dynamics and its implications for gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Murphy, Sedona — Yale University
- Study coordinator: Murphy, Sedona
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.