How chromatin affects liver development and healing
Official title: Chromatin Barriers Impacting Liver Development and Regeneration
Funded at University of Pennsylvania · NIH-11025658 · Data updated 2026-11-12
This study is looking at how certain proteins and DNA structures help liver cells grow and heal, which could help us understand how the liver works and recovers from injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $832,169 |
| NIH project number | 1R01DK141602-01 |
| Project ID | NIH-11025658 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with liver conditions or those interested in understanding liver development and regeneration.
✕Less likely to help
Patients with non-liver related conditions or those who are not affected by liver diseases may not benefit from this research.
What this research studies
This research investigates the role of chromatin and transcription factors in the development and regeneration of liver cells, known as hepatocytes. By utilizing advanced imaging technologies and genetic modifications, the team aims to understand how these molecular interactions influence liver function and cell fate. The study will explore both embryonic liver development and the regenerative processes in adult livers, providing insights into how different liver zones respond to injury and maintain homeostasis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver diseases and better strategies for liver regeneration.
How similar studies have gone: Previous research has shown promising results in understanding liver development and regeneration through similar molecular approaches.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Zaret, Kenneth — University of Pennsylvania
- Study coordinator: Zaret, Kenneth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.