How chromatin affects DNA processes
Chromatin-mediated mechanisms of genome integrity
This study is looking at how a part of our DNA called chromatin helps control important processes like copying DNA, which could help us understand more about keeping our genetic material stable and healthy for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11079501 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin in regulating essential DNA processes such as transcription and replication. By using advanced techniques to map chromatin occupancy at a detailed level, the team aims to uncover how chromatin influences the selection and activation of DNA replication origins. The study focuses on understanding the mechanisms that control helicase activity, which is crucial for DNA unwinding and synthesis. Patients may benefit from insights gained about DNA integrity and its implications for genetic stability.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions related to DNA replication and repair.
Not a fit: Patients with conditions unrelated to DNA processes or chromatin function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA integrity, potentially impacting treatments for genetic disorders.
How similar studies have performed: Other research has shown success in understanding chromatin's role in DNA processes, indicating that this approach is built on established findings.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Macalpine, David M — Duke University
- Study coordinator: Macalpine, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.