How cholesterol regulation affects Alzheimer's disease and brain function
Regulation of cholesterol by y-secretase and ApoE: Implications for AD pathogenesis and synaptic function
This study is looking at how cholesterol levels might affect the development of Alzheimer's disease and how it impacts brain connections, with the hope of finding new ways to help people understand and manage their cognitive decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11076774 on NIH RePORTER |
What this research studies
This research investigates the role of cholesterol regulation in the development of Alzheimer's disease (AD) and its impact on brain synapses. It focuses on the mechanisms by which γ-secretase and ApoE influence the accumulation of amyloid-beta (Aβ), a protein linked to AD. By exploring genetic factors and their effects on lipid metabolism and inflammation, the study aims to uncover new insights into AD pathogenesis. Patients may benefit from a better understanding of how cholesterol levels relate to cognitive decline and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting cholesterol regulation.
How similar studies have performed: Previous research has shown promising results in understanding the role of amyloid-beta in Alzheimer's disease, but this specific approach to cholesterol regulation is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sudhof, Thomas C. — Stanford University
- Study coordinator: Sudhof, Thomas C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.