How Chlamydia infections affect cell growth and structure
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
This study is looking at how the Chlamydia infection affects our cells by causing them to lose tiny structures called primary cilia and start dividing again, which could help us understand more about how this common infection works in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10875498 on NIH RePORTER |
What this research studies
This research investigates how Chlamydia trachomatis, a common bacterial infection, affects host cells by causing the loss of primary cilia and prompting cells to re-enter the cell cycle. The study will explore the mechanisms behind these changes, focusing on the AurA regulatory pathway and its role in cell cycle progression. By using advanced cell culture techniques, researchers aim to uncover the relationship between these cellular changes and the infection process itself. This could lead to a better understanding of how Chlamydia infections operate at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Chlamydia trachomatis infections.
Not a fit: Patients who are not infected with Chlamydia or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating Chlamydia infections and related complications.
How similar studies have performed: While the specific interactions being studied are novel, previous research has shown that understanding host-pathogen interactions can lead to significant advancements in treatment strategies.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Suetterlin, Christine — University of California-Irvine
- Study coordinator: Suetterlin, Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.