How Chlamydia bacteria control their survival inside human cells
Regulation of homotypic fusion by Chlamydia
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-11030811
This study is looking at how the Chlamydia bacteria, which can cause infections and even blindness, manage to live and grow inside our cells, focusing on a special protein that helps them do this, with the hope of finding better ways to prevent and treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11030811 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacterium Chlamydia trachomatis, a leading cause of sexually transmitted infections and infectious blindness, survives and replicates within human cells. The focus is on understanding the role of a specific protein, IncA, which is crucial for the fusion of compartments where the bacteria live. By exploring the mechanisms that regulate this fusion, the research aims to uncover new insights into Chlamydia's pathogenicity and its interaction with host cells. This could lead to better strategies for preventing and treating infections caused by this neglected pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections, particularly those experiencing severe symptoms or complications.
Not a fit: Patients who are not infected with Chlamydia or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for Chlamydia infections, potentially reducing the incidence of related diseases.
How similar studies have performed: While research on Chlamydia has been ongoing, the specific focus on the regulatory mechanisms of homotypic fusion is relatively novel and has not been extensively tested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAUMET, FABIENNE MICHELLE — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: PAUMET, FABIENNE MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus