How children's kidneys move and clear medicines as they grow
Ontogeny of drug transport
This project uses safe blood and urine markers to learn how children's kidneys transport and clear medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11321809 on NIH RePORTER |
What this research studies
Researchers will measure drug transporter levels in archived and new pediatric kidney tissue and search for natural substances in blood and urine that reflect transporter activity. They will collect and analyze blood and urine samples across newborns, infants, children, and adolescents to identify non-invasive biomarkers of kidney drug transport. Those biomarker data will be combined into age-specific pediatric physiologically-based pharmacokinetic (PBPK) computer models to predict medicine handling at different ages. The approach aims to fill gaps in how the kidney matures so dosing for kidney-cleared drugs can be safer and more accurate for children.
Who could benefit from this research
Good fit: Children and adolescents — including newborns, infants, and teens — who are taking medicines cleared by the kidneys or who can provide small blood or urine samples.
Not a fit: Adults and people who cannot provide blood or urine samples or who are not taking kidney-cleared medicines are unlikely to receive direct benefit.
Why it matters
Potential benefit: Could help doctors choose safer, more accurate medicine doses for children based on age and kidney function.
How similar studies have performed: Similar methods and PBPK models have worked well for liver drug handling, but using blood/urine biomarkers to map kidney transporter maturation in children is a newer application.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Prasad, Bhagwat — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Prasad, Bhagwat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.