How childhood immune development affects vaccine response and asthma risk
Official title: Proteomics and Metabolomics Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma
Funded at Boston Children's Hospital · NIH-11051830 · Data updated 2026-11-12
This study is looking at how children's immune systems grow and change in their early years, and how this affects their reactions to vaccines, chances of getting respiratory infections, and risk of asthma, so we can find ways to help kids stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 10, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $191,753 |
| NIH project number | 5U19AI168643-04 |
| Project ID | NIH-11051830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0 to 11 years, particularly those with a history of respiratory infections or asthma.
✕Less likely to help
Patients outside the age range of 0 to 11 years or those without respiratory issues or asthma may not benefit from this research.
What this research studies
This research investigates how the immune system develops in early childhood and how this affects responses to vaccines, susceptibility to respiratory infections, and the risk of developing asthma. By analyzing biological markers and immune responses in children, the study aims to identify specific immune profiles that may indicate a higher risk for these conditions. The approach involves collecting and analyzing blood samples to create detailed molecular maps of immune development. This information could help in identifying children who may benefit from targeted interventions to improve their health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better identification of children at risk for poor vaccine responses and asthma, allowing for earlier interventions.
How similar studies have gone: Previous research has shown promise in understanding immune development and its impact on health, suggesting that this approach could yield valuable insights.
Where this research is happening
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Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Steen, Hanno — Boston Children's Hospital
- Study coordinator: Steen, Hanno
Related research
Other NIH-funded projects on the same topics.
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IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
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IDEAL project helps predict vaccine response, infections, and asthma in early childhood
A Child-focused program will collect and share saliva, blood, and tissue samples from diverse infants to find biological patterns that predict how vaccines work, how respiratory infections occur, and who develops asthma.
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Understanding how early-life immune development affects vaccine responses and asthma risk in children
This project uses lab-grown human immune cells from infants and young children to explore why some kids respond poorly to vaccines and are more prone to respiratory infections and asthma.
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Multi-omic endotypes of vaccine response, respiratory infections, and asthma in children
A parent-friendly look at how early-life immune development shapes how kids respond to vaccines and stay free from lung infections and asthma, using advanced biological profiling.
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IDEAL: How the microbiome shapes vaccine response, infections, and asthma in kids
This project uses data from thousands of children to understand how the microbiome affects vaccines, respiratory infections, and asthma.
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IDEAL: How babies’ immune systems shape vaccines, infections and asthma
A large NIH project will build a cloud-based system to map how early-life immune development relates to vaccine responses, respiratory infections, and asthma in children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.