How childhood adversity affects smoking risk
Neurobehavioral mechanisms linking childhood adversity to increased risk for smoking
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11092128
This study is looking at how tough experiences in childhood might affect young adults' chances of smoking and using drugs, and it will explore how their brains respond to nicotine to help us understand this connection better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11092128 on ClinicalTrials.gov |
What this research studies
This research investigates how adverse childhood experiences (ACEs) influence the likelihood of smoking and substance use disorders. It focuses on young adults with varying histories of ACEs and examines the brain mechanisms that may contribute to increased smoking risk. Participants will undergo neuroimaging and receive nicotine nasal spray to assess their reactions and the reinforcing effects of nicotine. The goal is to better understand the relationship between childhood adversity and smoking behavior.
Who could benefit from this research
Good fit: Ideal candidates are young adults aged 21 and older with a history of adverse childhood experiences.
Not a fit: Patients without a history of adverse childhood experiences or those who are already regular smokers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions for individuals at risk of smoking due to childhood adversity.
How similar studies have performed: Previous research has shown that understanding the neurobehavioral mechanisms of addiction can lead to effective prevention and treatment strategies, suggesting potential success for this approach.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWEITZER, MAGGIE M — DUKE UNIVERSITY
- Study coordinator: SWEITZER, MAGGIE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder