How chemotherapy affects blood vessel signals and cancer cell resistance
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
This study is looking at how chemotherapy affects the signals from blood vessels that might help cancer cells survive, and it's aimed at finding new ways to make those cancer cells more responsive to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11004115 on NIH RePORTER |
What this research studies
This research investigates how chemotherapy influences the signals released by blood vessels, which may help cancer cells survive treatment. It focuses on a specific area where cancer cells reside, known as the perivascular niche, and how these interactions can lead to resistance against chemotherapy. By studying the factors secreted by blood vessels in response to chemotherapy, the research aims to find new ways to make cancer cells more sensitive to treatment. The approach includes using pre-clinical models to test these interactions and their effects on cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast cancer who are undergoing or have undergone chemotherapy.
Not a fit: Patients with non-breast cancers or those who are not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by overcoming resistance to chemotherapy.
How similar studies have performed: Previous research has shown promising results in targeting the interactions between cancer cells and their vascular environment, indicating potential for success in this approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Ghajar, Cyrus M — Fred Hutchinson Cancer Center
- Study coordinator: Ghajar, Cyrus M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.