How changing treatments affect repeated kidney problems in children
Causal effects of time-varying treatments on recurrent event outcomes
This project looks at how changing medication doses over time affect repeated kidney-related events in children with chronic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11176173 on NIH RePORTER |
What this research studies
This work will create new statistical methods to understand whether and how treatments that change over time influence repeated kidney problems such as proteinuria relapses in children. The team will build models that handle time-dependent factors and competing risks, test their accuracy with computer simulations, and then apply them to real-world data from pediatric kidney cohorts and electronic health records. By using data from children already followed in studies like CKiD and hospital records, researchers hope to estimate how dose changes of renin-angiotensin-aldosterone system inhibitors affect remission rates and later outcomes. The approach focuses on observational data rather than randomized trials, so it relies on advanced methods to separate treatment effects from other changing health factors.
Who could benefit from this research
Good fit: Children and adolescents with chronic kidney disease, especially those who have had repeated proteinuria or are taking RAAS inhibitor medications, would be most relevant to this research.
Not a fit: Adults with kidney disease or children without chronic kidney disease or without recurrent kidney events are unlikely to be directly impacted by this project.
Why it matters
Potential benefit: If successful, this work could help doctors choose medication doses over time to lower the chance of repeated kidney problems in children with chronic kidney disease.
How similar studies have performed: Related statistical approaches like marginal structural models have informed single-event treatment questions before, but applying them to repeated pediatric kidney events is new and largely untested.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zee, Jarcy — Children's Hosp of Philadelphia
- Study coordinator: Zee, Jarcy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.