How changing diets can alter our taste for sweetness and help reduce sugar intake

Diet-induced modification of sweet taste perception and preference: A potential strategy to aid in population-wide reduction in sugar intake

NIH-funded research Monell Chemical Senses Center · NIH-10454866

This study is looking at whether slowly reducing the sugar in foods and drinks can help people get used to less sweetness over time, making it easier for them to cut back on sugar in their diets.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionMonell Chemical Senses Center NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-10454866 on NIH RePORTER

What this research studies

This research investigates whether modifying the sugar content in foods and beverages can help people adjust their taste preferences over time, leading to a reduction in sugar consumption. By gradually decreasing the amount of added sugars in commercially available products, the study aims to determine if individuals can acclimate to lower sweetness levels, similar to how people adapt to lower sodium diets. The research will involve controlled trials to assess changes in taste perception and preference among participants, providing valuable insights into dietary habits and health outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in modifying their sugar consumption habits.

Not a fit: Patients who have specific dietary restrictions or conditions that prevent them from consuming modified sugar products may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to effective strategies for reducing sugar intake across populations, potentially improving overall health and reducing the risk of related diseases.

How similar studies have performed: Previous research on sodium reduction has shown success in helping individuals adjust their taste preferences, suggesting that a similar approach for sugar may also be effective.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cardiovascular Diseasescardiovascular disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.