How changes to the brain's norepinephrine transporter affect amphetamine reward
The role of norepinephrine transporter phosphorylation in amphetamine reward
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11187017
This project looks at how chemical changes to a brain protein called the norepinephrine transporter change how rewarding amphetamines feel for adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11187017 on ClinicalTrials.gov |
What this research studies
From a patient's viewpoint, researchers are studying a specific chemical switch (phosphorylation) on the norepinephrine transporter that may change how strongly amphetamines drive rewarding behavior. They use genetically engineered mice that cannot be phosphorylated at two key sites and also use viral tools to block this modification in specific brain regions. The team measures real-time norepinephrine signals in the brain with high-speed chronoamperometry and microdialysis while observing animal behavior after amphetamine exposure. The goal is to connect these molecular changes to drug-related behavior so new treatment targets for stimulant addiction can be identified.
Who could benefit from this research
Good fit: This work is most relevant to adults (21+) with amphetamine or other stimulant use disorder who are interested in future medication options.
Not a fit: Because the project is preclinical and carried out in animals, patients will not receive immediate treatment or direct clinical benefit from this grant.
Why it matters
Potential benefit: If successful, this work could point to new molecular targets for medications to reduce amphetamine craving and relapse.
How similar studies have performed: Prior animal and lab studies from this group and others suggest NET phosphorylation affects stimulant-related behaviors, but translating these findings into effective human treatments has not yet been achieved.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAYANTHI, LANKUPALLE D — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: JAYANTHI, LANKUPALLE D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.