How changes in tubulin phosphorylation affect breast cancer behavior
Official title: Phosphorylation of α/β Tubulin is a 'Toggle Switch' in Human Breast Cancer
Funded at Queens College · NIH-10850006 · Data updated 2026-11-12
This study is looking at how certain proteins in breast cancer cells can change when they are modified by enzymes, which might help us understand how these changes affect cancer growth and movement, ultimately aiming to find better treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Queens College NIH-funded |
| Lab location | 1 site (Flushing, United States) |
| Project start | August 5, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $170,349 |
| NIH project number | 1R16GM153696-01 |
| Project ID | NIH-10850006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer who may benefit from novel treatment strategies targeting microtubule dynamics.
✕Less likely to help
Patients with non-breast cancer types or those whose cancer is not influenced by microtubule dynamics may not benefit from this research.
What this research studies
This research investigates the role of phosphorylation in the α/β-tubulin proteins, which are crucial for the structure and function of cells, particularly in breast cancer. The study focuses on how specific enzymes, Protein Kinase C and cyclin-dependent kinase-1, influence the growth and movement of breast cancer cells by toggling the phosphorylation states of tubulin. By using advanced molecular simulations and experimental techniques, the researchers aim to understand how these changes can lead to different cancer behaviors, potentially providing new insights into treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that target the mechanisms controlling breast cancer cell growth and movement.
How similar studies have gone: Previous research has shown promising results in targeting microtubule dynamics in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
-
Queens College
Flushing, United States Active
Researchers
- Principal investigator: Rotenberg, Susan a. — Queens College
- Study coordinator: Rotenberg, Susan a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.