How changes in the coronavirus spike protein affect its ability to enter human cells
Impacts of Adaptive Coronavirus Evolution on Viral Membrane Fusion
['FUNDING_R21'] · LOYOLA UNIVERSITY CHICAGO · NIH-10929470
This study is looking at how changes in a part of the SARS-CoV-2 virus called the spike protein affect its ability to enter human cells, which could help us understand why some variants are better at causing infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-10929470 on ClinicalTrials.gov |
What this research studies
This research investigates how the evolving spike protein of the SARS-CoV-2 virus, particularly its S2 domain, impacts the virus's ability to fuse with human cell membranes. By examining various mutations in the spike protein, the study aims to understand how these changes influence the virus's entry into cells. The research employs advanced assay systems, including virus-like particles, to analyze the dynamics of the spike protein during the fusion process. This could provide insights into how new variants of the virus become more effective at infecting human cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of COVID-19 infection, particularly those with underlying health conditions that may exacerbate the disease.
Not a fit: Patients who are not affected by COVID-19 or those who have already recovered from the virus may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating COVID-19 by targeting the mechanisms that allow the virus to enter human cells.
How similar studies have performed: Other research has shown success in understanding viral entry mechanisms, making this approach promising for further advancements in COVID-19 treatment.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALLAGHER, THOMAS MILLER — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: GALLAGHER, THOMAS MILLER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.