How changes in tau proteins affect Alzheimer's disease progression
The Influence of Tau Post-Translational Modifications on the Propagation of Tau Pathology in Alzheimer's Disease
This study is looking at how changes to tau proteins affect their movement in the brain during Alzheimer's disease, using human brain cells to help find new ways to slow down or stop the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11123180 on NIH RePORTER |
What this research studies
This research investigates how specific modifications to tau proteins influence their spread in the brain during Alzheimer's disease. By using human-derived neurons, the study aims to understand how these modified tau proteins propagate from one cell to another and contribute to the disease's progression. The researchers will explore the mechanisms of tau's movement and its ability to form aggregates, which are critical in the development of Alzheimer's symptoms. This work could provide insights into potential therapeutic targets for slowing or stopping the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dickson, John R — Massachusetts General Hospital
- Study coordinator: Dickson, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.